Mouse Models of 22q11.2-Associated Autism Spectrum Disorder
نویسندگان
چکیده
منابع مشابه
Mouse Models of 22q11.2-Associated Autism Spectrum Disorder
Copy number variation (CNV) of human chromosome 22q11.2 is associated with an elevated rate of autism spectrum disorder (ASD) and represents one of syndromic ASDs with rare genetic variants. However, the precise genetic basis of this association remains unclear due to its relatively large hemizygous and duplication region, including more than 30 genes. Previous studies using genetic mouse model...
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To explore the interplay between new mutation, transmission, and gender bias in genetic disease requires formal quantitative modeling. Autism spectrum disorders offer an ideal case: they are genetic in origin, complex, and show a gender bias. The high reproductive costs of autism ensure that most strongly associated genetic mutations are short-lived, and indeed the disease exhibits both transmi...
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ژورنال
عنوان ژورنال: Autism- Open Access
سال: 2012
ISSN: 2165-7890
DOI: 10.4172/2165-7890.s1-001